Wiles: CBT Effectiveness Flashcards

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What was the aim of the Wiles study on CBT?

To test if adding CBT to usual care helps people with depression more than usual care alone.

Who took part in the Wiles study?

469 adults from UK GP surgeries who still had depression while on antidepressants.

What does treatment-resistant depression mean in this study?

Still having depression after at least six weeks on antidepressant medicine.

How were participants put into groups?

By chance. One group had usual care. The other had usual care plus CBT.

What was usual care in the Wiles study?

Antidepressant medicine and GP care.

How much CBT did the CBT group get?

Up to 12–18 sessions over about six months, with a trained therapist.

What did the researchers measure to track change?

Depression scores using the Beck Depression Inventory (BDI-II), especially at six months.

What was the main result at six months?

About 46% on CBT plus medicine had a 50% drop in symptoms, versus about 22% on medicine only.

Did the benefits of CBT last over time?

Yes. The CBT group still did better at 12 months.

What was the conclusion of the Wiles study?

Adding CBT to medicine is an effective treatment for people not helped enough by medicine alone.

Give one strength of the Wiles study.

It was done in GP surgeries, so the results apply well to real-life care.

Give one limitation of the Wiles study.

People knew if they got extra CBT, which could affect how they rated their symptoms.