Disease-associated Alleles and Genetic Risk Flashcards

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What is an allele?

An allele is a different version of the same gene.

What is a disease-associated allele?

It is an allele that makes it more likely, but not certain, that you will get a disease.

What is meant by genetic risk of a disease?

It is the chance of getting a disease because of the alleles you have.

How is a disease-causing allele different from a disease-associated allele?

A disease-causing allele usually leads to the disease, but a disease-associated allele only raises the chance.

Why do people with a disease-associated allele not always get the disease?

Because other genes, lifestyle, and the environment also affect whether the disease develops.

Give two lifestyle factors that can change your risk of disease.

Examples include diet, smoking, exercise, and alcohol use.

How do scientists find disease-associated alleles using genomes?

They compare genomes of many people with a disease to those without it and look for alleles that are more common.

If an allele doubles your risk of a disease, does it mean you will get the disease?

No, it only means your chance is higher than average, not that you will get it for sure.

Why does having close relatives with a disease suggest higher genetic risk?

Because you are more likely to share alleles with your close relatives.

How can knowing you have a disease-associated allele help you?

It can help you choose healthier habits and have check-ups to lower or manage your risk.